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KMID : 0382420000260020097
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Korean Journal of Environmental Health Society
2000 Volume.26 No. 2 p.97 ~ p.107
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The Concentrations of PCBs in the Serum and Their Predictors of Exposure in Korean Women
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Min Sun-Young
Koo Jung-Wan
Jeong Mun-Ho
Lee Kang-Sook
Roh Young-Man
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Abstract
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PCBs [Polychlorinated biphenyls] are halogenated aromatic compounds with the empirical formula C_12H_(10-n)Cl_n(n=1~10), and are a mixture of possible 209 different chlorinated congeners. PCBs were widely used as dielectric fluids for capacitors, transformers, plasticizers, lubricant inks, and paint additives. Once released into the environment, PCBs persist for years because they are so resistant to degradation. In addition to their persistence in the environment, PCBs in ecological food chains undergo biomagnification because of their high degree of lipophilicity. In 1970s, the worldwide production of PCBs was ceased and the import of PCBs was prohibited since 1983 in Korea. In spite of these actions, many PCBs seem to be still in use. The environmental load of PCBs will continue to be recycled through air, land, water, and the biosphere for decades to come. This study was conducted to measure the concentrations of PCBs in the serum samples of 112 women by GC/MSD(Hewlett Packard 5897 Gas Chromatography-Mass Chromatography Detector) and GC/ECD(Hewlett Packard 5890 series-Ⅱ gas chromatography-Electron capture detector, U.S.A). The main results of this study were as follows; The mean and standard deviation of serum PCBs were 3.613, 0.759 ppb, respectively and median of it was 3.828 ppb. The correlation coefficients of the concentrations of 13 PCB congeners ranged from 0.7913 to 0.9985 and were significantly correlated between each items(p=0.0001). The PCB concentrations were positively associated with age(simple linear regression; R^2=0.86, β^=0.08023, p<0.001) and with total lipids in serums(simple linear regression; R^2=0.7058, β^=0.00486, p<0.001). The age adjusted model (Y=β_0+β_1age +β_2X) was applied for possible predictors of PCBs levels in serum. For BMI(Body Mass Index), major residential area, and fish, meat, and dairy consumption, there was no association with PCBs levels. Also, there was negative association for the number of pregnancy and lactation period with PCBs levels.
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